Does hyperbaric oxygen therapy positively change organic dysfunctions in bitches with sepsis caused by cystic endometrial hyperplasia-pyometra

Abstract

Experimental models have shown positive outcomes associated with hyperbaric oxygen therapy (HO) when it comes to reducing mortality rates in sepsis patients. The aim of the present study is to assess HO impact on the microperfusion of sepsis bitches with Cystic Endometrial Hyperplasia-Pyometra (CEH-P) based on SOFA SCORE (Sequential Organ Failure Assessment) to quantify and monitor organic dysfunction degree. Eight (8) bitches diagnosed with CEH-P were included in the study; they were randomly split into two groups: G1 (ovariohysterectomy + clinical therapy) and G2 (ovariohysterectomy + clinical therapy + HO). All bitches in G2 were subjected to three HO sessions, at 24-h time interval between sessions. All animals showed at least one organic dysfunction due to sepsis. Animals in G2 presented significant improvement in clinical conditions and initial 51% reduction in SOFA scoring. On the other hand, animals in G1 recorded 29% reduction in this variable. Hyperbaric therapy was effective in reducing bitches’ organic dysfunction with sepsis caused by CEH-P; however, it did not have significant reflex on Central Venous Oxygen Saturation (SvcO2).